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Opening Session

9:00 - 9:30 Check in, coffee and poster setup
9:30 - 9:35 Welcome (Jianhan Chen, UMass Amherst)
9:35 - 9:45 Introduction of IALS and Keynote Speaker (Peter Chien, UMass IALS M2M Director)
9:45 - 10:15 Opening Keynote Speaker : Lila Gierasch (UMass Amherst)
How Hsp70 molecular chaperones recognize substrates that need their help: Selective promiscuity

Topical Session 1: Dynamic interactions of proteins (Chair: Xinqiang Ding, Tufts)

10:20 - 10:40 Haribabu Arthanari (Harvard)
A tale of tails: The functional role of disordered regions in the human proteome
10:45 - 10:55 Nabin Kandel (RPI)
Tau and Lipid Bilayer Interactions Are Driven by Electrostatics and Inhibited by Cholesterol
10:58 - 11:08 Yeseul Lee (UMass Amherst)
Push-and-pull mechanism of single-molecule movement of alpha-Synuclein under nano-confinement

11:10 - 11:30 : Coffee Break

Topical Session 2: Biomolecular folding and assembly (Chair: Sweta Vangaveti, SUNY Albany)

11:30 - 11:50 Ashley Carter (Amherst College)
DNA folding with protamine
11:55 - 12:05 Anna Bock (Brown)
Characterizing the conserved pH sensor in the yeast prion protein Sup35
12:08 - 12:18 George Makhatadze (RPI)
Experimental and computational studies of the effects of high hydrostatic pressure on biomolecular interactions

Lunch and Poster Viewing (12:20 - 2:30)

We ask that presenters be available at their posters from 1:00-1:45 (odd numbered) or 1:45-2:30 (even numbered)

Topical Session 3: Drug and biologics design (Chair: Sean Edington, UNH)

2:30 - 2:50 Paul Robustelli (Dartmouth)
Targeting Intrinsically Disordered Proteins and Biomolecular Condensates with Small Molecule Drugs
2:55 - 3:05 Jeffrey D. Tamucci (UConn)
Powering the powerhouse: MD simulations illustrate how mitochondria-targeted tetrapeptides alter membrane electrostatics and have the potential to improve mitochondrial bioenergetics
3:08 - 3:18 Jeanne Hardy (UMass Amherst)
Harnessing protease reactions for detection and treatment of viral infection

Topical Session 4: Enzyme structure, function and engineering (Chair: Constance J Jeffery, UIC)

3:20 - 3:40 Erika Taylor (Wesleyan)
Aminoglycosides Revisited: Evidence for Inhibition of Heptosyltransferase I from Escherichia coli
3:45 - 3:55 Bhumika Jayee (Northeastern)
Computational study of a red light-driven reaction in a flavin-dependent photoenzyme
3:58 - 4:08 Bao Nguyen (UMass Amherst)
Mechanistic insights into Ca2+ sensitivity regulation of CaMKII

4:10 - 4:30 : Coffee Break

Closing Session

4:30 - 4:35 Keynote Introduction (M. Muthukumar, UMass Amherst)
4:35 - 5:05 Closing Keynote Speaker : Ken Dill (SUNY Stony Brook)
The Origins of Life: An uncanny resemblance to the old Protein Folding Problem
5:10 Closing remarks/poster removal